Several studies have shown that berberine may modulate the gut microbiota through enriching short-chain fatty acid (SCFA)-producing bacteria and reducing microbial diversity. This in turn inhibits dietary polysaccharide degradation and decreases caloric intake in the gut, which may improve energy metabolism and intestinal health; anti-inflammatory effects; and immune regulatory effects.
There’s a strong correlation between blood sugar and weight loss. Research on berberine for weight loss and fat-burning activity is limited but promising. In one 12-week study, subjects lost about 2.3% body weight — or 5 pounds — and lowered BMI and body fat percentage by 3.6% with a dosage of 3,500 mg per day.[*] Another 3-month study revealed a drop in BMI, from 31.5 to 27.4, in obese individuals, as well as a reduction in waist circumference.[*]
Berberine may activate the ‘metabolic master switch’: An energy-stabilizing enzyme found inside cells, AMPK (adenosine monophosphate kinase), is known as a ‘metabolic master switch’ due to its positive influence on metabolism.[*] It’s believed that this helps improve insulin sensitivity at the cellular level.
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